CVX-300

The Spectranetics CVX-300 Excimer Laser System:
Proven technology for the treatment of multiple
cardiovascular procedures.

Spectranetics manufactures and markets the only excimer laser system and disposable catheters for the treatment of peripheral and coronary arterial disease and lead extraction and management.

The Science of Spectranetics’ Excimer Laser Ablation

Photoablation is the use of light to break down, vaporize and remove matter. Spectranetics CVX-300® Excimer Laser facilitates photoablation via a variety of Spectranetics catheters to remove arterial plaques and binding scar tissue surrounding cardiac pacemaker ICD leads.

The mechanisms of actions are

Photochemical: Breaking molecular bonds

• UV light pulse hits tissue for 135-billionths of a second (135ns); the duration of the laser pulse
• 50 microns penetration
• Billions of molecular bonds fractures per pulse
• After 135-billionths of a second, laser energy is not emitted

Photothermal: Producing thermal energy

• Absorption vibrates the molecular bonds of the plaque
• Vibration of bonds heats intracellular water
• Water vaporizes, molecules break apart, and cells rupture
• Expanding vapor bubble forms in 100-millionths of a second (100 µs)
  • 1,000 times the duration of the actual laser energy emission

Photomechanical: Creating kinetic energy

• Expansion and collapse of vapor bubble breaks down tissue and clears byproducts away from tip
• Byproducts of ablation are water, gas, and small particles
• Entire process time per pulse is 400-millionths of a second (400 µs)
  • 4,000 times the duration of the actual laser energy emission

D006174-01